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زیست شناسی::
چرخه سلولی
Compared to myoepithelial stem cells, interstitial stem cells are paused in the G2 phase of the cell cycle for a longer period and cycle at a faster rate (Buzgariu et al. 2014), suggesting that the interstitial stem cells are poised to immediately respond to a need for cell replacement through rapid proliferation.
After that, the ability is lost, presumably because the cardio- myocytes withdraw from the cell cycle (Porrello et al. 2011).
It is known, though, that cardiomyocytes in adult mammals (as in adult zebrafish) will respond to a heart attack by re-entering the cell cycle, thus contributing to injury repair (Senyo et al. 2013).
Surprisingly, the regenerating liver cells do not fully dedifferentiate when they reenter the cell cycle.
These mature cells, which are usually not dividing, are instructed to rejoin the cell cycle and proliferate until they have compensated for the missing part.
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